Genome-wide analyses on loss of heterozygosity in hepatocellular carcinoma in Southern China
โ Scribed by Sheng-Ping Li; Hui-Yun Wang; Jing-Qin Li; Chang-Qing Zhang; Qi-Sheng Feng; Ping Huang; Xin-Juan Yu; Li-Xi Huang; Qi-Wang Liang; Yi-Xin Zeng
- Book ID
- 119526575
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 476 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0168-8278
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We investigated 24 hepatocellular carcinomas in Japan to find loss of heterozygosity with 15 polymorphic DNA markers that detect allelic losses at specific chromosome loci. Loss of heterozygosity on chromosomes lOq, 17p and 22q was detected in 3 of 12 (26%), 9 of 21 (43%) and 5 of 15 (33%) informati
A powerful way to identify driver genes with causal roles in carcinogenesis is to detect genomic regions that undergo frequent alterations in cancers. Here we identified 1,241 regions of somatic copy number alterations in 58 paired hepatocellular carcinoma (HCC) tumors and adjacent nontumor tissues