Genistein treatment reduces arterial contractions by inhibiting tyrosine kinases in ovariectomized hypertensive rats
โ Scribed by Riikka Nevala; Markus Lassila; Piet Finckenberg; Kirsi Paukku; Riitta Korpela; Heikki Vapaatalo
- Book ID
- 114015052
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 401 KB
- Volume
- 452
- Category
- Article
- ISSN
- 0014-2999
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This study was one of a series designed to analyse signalling events in the hippocampus after induction of long-term potentiation (LTP). The specific purpose was to further analyse changes associated with tyrosine kinase activation after earlier observations. Among the earlier observations were the
In conclusion, the report by Casey and colleagues is based on the use of two pharmacological inhibitors that have nonspecific effects and no attempt was made to verify their specificity. This lead the authors to ambitious conclusions on the involvement of tyrosine kinases on LTP in perforant path-gr
## Abstract A great deal of recent evidence points to a role for tyrosine kinase in expression of LTP. Data have been presented that are consistent with the idea that tyrosine phosphorylation of proteins occurs in both the presynaptic and postsynaptic areas. In this study, we set out to investigate