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Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein

✍ Scribed by Daniela B. Pereira; Carlos B. Duarte

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 53 KB
Volume: 13
Category: Article
ISSN: 1050-9631
DOI: 10.1002/hipo.10148

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✦ Synopsis

In conclusion, the report by Casey and colleagues is based on the use of two pharmacological inhibitors that have nonspecific effects and no attempt was made to verify their specificity. This lead the authors to ambitious conclusions on the involvement of tyrosine kinases on LTP in perforant path-granule cell synapses, that cannot be inferred from the data presented in this article.

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