Rapamycin inhibits cdk4 activation, p 21
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Anne-Marie Gaben; Cecile Saucier; Monique Bedin; VΓ©ronique Barbu; Jan Mester
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Article
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2003
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John Wiley and Sons
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French
β 241 KB
## Abstract Rapamycin, a bacterial macrolide antibiotic, is a potent immunosuppressant agent that blocks cell proliferation by inhibiting the G1/S transition in several cell types. In sensitive cells, rapamycin inhibits the phosphorylation of p70 S6K and of Rb; however, the precise mechanisms invol