Genetics of the Lp lipoprotein in Japanese-Americans
✍ Scribed by Dr. Newton E. Morton; Kåre Berg; Gösta Dahlen; Robert E. Ferrell; George G. Rhoads; D. C. Rao
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 538 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
Segregation analysis of four Lp assays on 557 children in 227 families reveals a dominant major gene and a residual heritable component that may reflect one or more alleles of weaker effect. Close or moderate linkage to esterase-D (ESD) is excluded.
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Lp(a) lipoprotein [Lp(a)] was quantified in 1251 adults, including 300 motherfather-offspring triplets, by a sensitive radial immunodiffusion assay. Lp(a) was not correlated with age, sex, or cholesterol or glyceride concentrations. Significant correlations were found between mother-offspring (r = 0
Lp lipoproteins have been prepared by a mild method from the serum of a large number of individuals. Approximately 25%o of the individuals tested showed the presence of a double Lp peak in analytical ultracentrifuge diagrams. These double peaks were designated Lp(a)-I and Lp(a)-2 to distinguish them