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Genetics of haemoglobin H and α-thalassaemia

✍ Scribed by R. D. KOLER; R. T. JONES; P. WASI; S. POOTRUKUL


Book ID
115247222
Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
529 KB
Volume
34
Category
Article
ISSN
0003-4800

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The question, "Is Hb G alpha Philadelphia linked to alpha-thalassaemia?" was first posed because the abnormal haemoglobin is found in heterozygotes at a concentration greater than 25%, the proportion predicted from a 4 alpha-chain gene model. Globin chain biosynthesis was studied in a West Indian fa