Genetics of childhood acute lymphoblastic leukemia
β Scribed by Ching-Hon Pui
- Publisher
- Carden Jennings Publishing
- Year
- 2002
- Tongue
- English
- Weight
- 450 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0925-5710
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## Abstract Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involved in the biotransformation of a variety of xenobiotics present in organic solvents, tobac
## Abstract DNA per cell content was routinely recorded by singleβparameter flow cytometry in leukemic blasts from 473 children with acute lymphoblastic leukemia (ALL), enrolled in national studies ALL V, VI, and VII (1979β1991) of the Dutch Childhood Leukemia Study Group. The parameters bonemarrow
## Abstract High hyperdiploidy (51β67 chromosomes) is the most common cytogenetic abnormality pattern in childhood Bβcell precursor acute lymphoblastic leukemia (ALL), occurring in 25β30% of such cases. High hyperdiploid ALL is characterized cytogenetically by a nonrandom gain of chromosomes X, 4,