✦ LIBER ✦

Genetics of asthma and inflammation: the status

✍ Scribed by Miriam F Moffatt; William OCM Cookson

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 77 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)00024-2

No coin nor oath required. For personal study only.

✦ Synopsis

Genome-wide screens are consistently finding linkage between asthma-associated traits and specific chromosomal loci. Several loci coincide with linkages to other inflammatory diseases, suggesting the presence of common pathways in their pathogenesis. Candidate-gene studies have found an association between a CD14 polymorphism and IgE levels, suggesting a mechanism for the increased prevalence of allergic disease. A polymorphism in FcεRI-β shows parent-oforigin effects when associated with severe infantile eczema, further illustrating the complexity of gene-environment effects on the developing immune system.

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