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Genetics and biochemistry of resistance to axenomycin inSaccharomyces cerevisiae

✍ Scribed by S. Sora; O. Ciferri; G. Pasquale; G. E. Magni

Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
504 KB
Volume
2
Category
Article
ISSN
0172-8083

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✦ Synopsis

Axenomycin inhibits protein synthesis in vivo and in vitro in Saccharomyces cerevisiae. The antibiotic acts by binding to ribosomes, most probably to the large ribosomal subunit. Mutant strains resistant to axenomycin appear to contain ribosomes that are not inhibited by the antibiotic. The responsible gene has been mapped on the VII chromosome between the centromere and the leu1 gene.

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