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Genetically determined oxidation polymorphism and drug hepatotoxicity

✍ Scribed by Larrey, Dominique; Tinel, Marina; Amouyal, Gilles; Freneaux, Eric; Berson, Alain; Fouin-Fortunet, Hélène; Babany, Gérard; Letteron, Philippe; Iglicki, Franck; Slama, Jean-Louis


Book ID
123245333
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
406 KB
Volume
8
Category
Article
ISSN
0168-8278

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Genetically determined sparteine oxidati
✍ K. Orzechowska-Juzwenko; J. Pawlik; P. Niewiński; P. Milejski; J. Dembowski; J. 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 259 KB

The genetic oxidation polymorphism was determined in 160 healthy Polish volunteers from the southwest of Poland (Wroctaw region), using sparteine as a model drug. The results of a Polish population study revealed a bimodal distribution of the sparteine metabolic ratio and showed the existence of two