Genetically determined differences in drug metabolism as a risk factor in drug toxicity
โ Scribed by Eichelbaum, M.; Kroemer, H.K.; Mikus, G.
- Book ID
- 122015080
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 638 KB
- Volume
- 64-65
- Category
- Article
- ISSN
- 0378-4274
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
differences exist in the regulation of at least some of the P450s (10). As the molecular mechanisms that underlie induction of human liver P45Os are characterized, it is likely that cell-free assays will be developed to screen drugs for induction properties. These two reports describe recombinant D
A pharmacogenetic predisposition to thalidomide-induced neuropathy has been investigated. Differences of drug metabolism were examined in 16 patients with severe orogenital ulceration, who were treated with thalidomide (< 200 mg/day) for 0.3-5.0 years. Eight had evidence of early peripheral neuropat