✦ LIBER ✦
Identification of genetic differences in drug metabolism: Prediction of individual risk of toxicity or cancer
✍ Scribed by Daniel W. Nebert
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 448 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
differences exist in the regulation of at least some of the P450s (10). As the molecular mechanisms that underlie induction of human liver P45Os are characterized, it is likely that cell-free assays will be developed to screen drugs for induction properties.
These two reports describe recombinant DNA tests that can identify individuals having a defect in the cflochrome P450IID6 (CYP2DGkmediated oxidative metabolism of debrisoquine and more than two dozen other drum that are commonlv Drescribed. The Door 1.