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Genetic variation in the beta subunit of the high affinity IgE receptor and atopy and asthma

✍ Scribed by Julian Hopkin; William Cookson


Book ID
108687792
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
56 KB
Volume
36
Category
Article
ISSN
0954-7894

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IgE dysregulation is a major pathogenic feature of atopic dermatitis and other IgE-mediated allergic diseases such as asthma and rhinitis. Allergen complexed to IgE binds to the high affinity receptor for IgE (Fc epsilon RI) on the surface of epidermal Langerhans cells, mast cells and basophils, tri