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Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

✍ Scribed by Shirakawa, Taro; Li, Airong; Dubowitz, Michael; Dekker, James W.; Shaw, Ann E.; Faux, Jennie A.; Ra, Chisei; Cookson, William O.C.M.; Hopkin, Julian M.


Book ID
109916218
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
650 KB
Volume
7
Category
Article
ISSN
1061-4036

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IgE dysregulation is a major pathogenic feature of atopic dermatitis and other IgE-mediated allergic diseases such as asthma and rhinitis. Allergen complexed to IgE binds to the high affinity receptor for IgE (Fc epsilon RI) on the surface of epidermal Langerhans cells, mast cells and basophils, tri