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Genetic variation in SCN10A influences cardiac conduction

โœ Scribed by Chambers, John C; Zhao, Jing; Terracciano, Cesare M N; Bezzina, Connie R; Zhang, Weihua; Kaba, Riyaz; Navaratnarajah, Manoraj; Lotlikar, Amol; Sehmi, Joban S; Kooner, Manraj K

Book ID
109914562
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
582 KB
Volume
42
Category
Article
ISSN
1061-4036

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A homozygous SCN5A mutation in a severe,
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โœ Axel Neu; Michele Eiselt; Matthias Paul; Kathrin Sauter; Birgit Stallmeyer; Dirk ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 460 KB

Cardiac sodium channels are key players in the generation and propagation of action potentials in the human heart. Heterozygous mutations in the SCN5A gene have been found to be associated with long QT syndrome, Brugada syndrome, and sinus node dysfunction (SND). Recently, overlapping arrhythmia phe