Cardiac conduction defects associate with mutations in SCN5A
✍ Scribed by Schott, Jean-Jacques; Alshinawi, Connie; Kyndt, Florence; Probst, Vincent; Hoorntje, Theo M.; Hulsbeek, Miriam; Wilde, Arthur A.M.; Escande, Denis; Mannens, Marcel M.A.M.; Le Marec, Hervé
- Book ID
- 109494132
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 216 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/12618
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📜 SIMILAR VOLUMES
Cardiac sodium channels are key players in the generation and propagation of action potentials in the human heart. Heterozygous mutations in the SCN5A gene have been found to be associated with long QT syndrome, Brugada syndrome, and sinus node dysfunction (SND). Recently, overlapping arrhythmia phe
The long QT syndrome (LQT) is an inherited cardiac disorder that can cause sudden cardiac death among apparently healthy young individuals due to malignant ventricular arrhythmias. LQT was found to be caused by mutations in four genes LQT1, LQT2, LQT3 and LQT5, and linkage was reported for an additi