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Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease

✍ Scribed by Jenni Hyysalo; Ivana Stojkovic; Anna Kotronen; Antti Hakkarainen; Ksenia Sevastianova; Janne Makkonen; Nina Lundbom; Aila Rissanen; Ronald M Krauss; Olle Melander; Marju Orho-Melander; Hannele Yki-Järvinen

Book ID
115171097
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
253 KB
Volume
27
Category
Article
ISSN
0815-9319

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Genetic variation in PNPLA3 confers susc
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
✍ Romeo, Stefano (author);Kozlitina, Julia (author);Xing, Chao (author);Pertsemlid 📂 Article 📅 2008 🏛 Nature Publishing Group 🌐 English ⚖ 491 KB

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups. To identify genetic variants contributing to differences in hepatic fat content, we carried out a genome-wide association scan of nonsynonymous sequence variat