Genetic variation in insulin-like growth factor signaling genes and breast cancer risk amongBRCA1andBRCA2carriers
✍ Scribed by Susan L Neuhausen, Sean Brummel, Yuan Chun Ding…
- Book ID
- 120699596
- Publisher
- BioMed Central
- Year
- 2009
- Tongue
- English
- Weight
- 663 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr2414
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## Abstract Insulin‐like growth factor‐1 (IGF‐I), a potent mitogen, is hypothesized to influence breast cancer risk. In 3 previous studies, a polymorphism in the __IGF‐1__ gene (sequence repeat length) was associated with plasma IGF‐I level. We evaluated prospectively the relationships among a (CA)
## Abstract The evidence that high circulating levels of insulin‐like growth factor‐I (IGF‐I) are associated with an increased risk of breast cancer among premenopausal women lends credence to the hypothesis that genetic polymorphisms in the __IGF‐I__ gene may be involved in the disease. A populati
Insulin-like growth factor-I (IGF-I) has mitogenic and antiapoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions