We appreciate the comments of Leiro et al. on the role of the combined glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) null genotypes in determining the susceptibility to developing idiosyncratic drug-induced liver injury (DILI) as a general mechanism that occurs regard
Genetic variants of hepatic transporters and susceptibility to drug induced liver injury
β Scribed by Pallav Bhatnagar; Chris P. Day; Guruprasad Aithal; Munir Pirmohamed; William Bernal; Ann K. Daly
- Book ID
- 108287528
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 136 KB
- Volume
- 253
- Category
- Article
- ISSN
- 0300-483X
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π SIMILAR VOLUMES
on behalf of the Spanish Group for the Study of Drug-Induced Liver Disease Individual vulnerability to drug-induced liver injury (DILI) might result from deficiencies in the detoxification process, which determines the level of exposure to the reactive metabolite. We evaluated whether a genetically
The role of complement as potential activator for tissue macrophages and neutrophils was investigated in an experimental model of endotoxin-induced liver hjury in male Fischer rats. Iqjection of SaZmoneUa enteritidis endotoxin (1 mg/kg) into Corynebacterium purvum-pretreated animals (7 mg/kg, single