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Genetic variants in theRELNgene are associated with otosclerosis in multiple European populations

✍ Scribed by Isabelle Schrauwen; Megan Ealy; Erik Fransen; Kathleen Vanderstraeten; Melissa Thys; Nicole C. Meyer; Marcel Cosgarea; Alex Huber; Manuela Mazzoli; Markus Pfister; Richard J. H. Smith; Guy Van Camp

Publisher: Springer
Year: 2009
Tongue: English
Weight: 370 KB
Volume: 127
Category: Article
ISSN: 0340-6717
DOI: 10.1007/s00439-009-0754-2

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## Abstract ## Objective: Multiple sclerosis (MS) is a complex neurological disease. Genetic linkage analysis and genotyping of candidate genes in families with 4 or more affected individuals more heavily loaded for susceptibility genes has not fully explained familial disease clustering. ## Meth