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Genetic variability at the amyloid-β precursor protein locus may contribute to the risk of late-onset Alzheimer's disease

✍ Scribed by Fabienne Wavrant-De Vrièze; Richard Crook; Peter Holmans; Patrick Kehoe; Michael J. Owen; Julie Williams; Kim Roehl; Debomoy K. Laliiri; Shantia Shears; Jeremy Booth; William Wu; Alison Goate; Marie Christine Chartier-Harlin; John Hardy; Jordi Pérez-Tur


Book ID
117477799
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
86 KB
Volume
269
Category
Article
ISSN
0304-3940

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✍ Petra Nowotny; Xavier Simcock; Sarah Bertelsen; Anthony L. Hinrichs; John S.K. K 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 2 views

## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer