Medullary thyroid carcinoma occurs sporadically or as a part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. The MEN 2 gene has been identified as the RET proto-oncogene on chromosome 10. In MEN 2A, RET mutations are detectable in one of five cysteine codons within exons
โฆ LIBER โฆ
Genetic testing in endocrinology: lessons learned from experience with multiple endocrine neoplasia type 2 (MEN2)
โ Scribed by Camilo Jimenez; Robert F. Gagel
- Book ID
- 116511995
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 275 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1096-6374
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## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ protoโoncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRฮฑ
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