Genetic susceptibility and carcinogen-DNA adduct formation in human urinary bladder carcinogenesis
β Scribed by Fred F Kadlubar; Alaa F. Badawi
- Book ID
- 118411921
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 529 KB
- Volume
- 82-83
- Category
- Article
- ISSN
- 0378-4274
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Formation of DNA adducts and of water-soluble metabolites was studied in monocytes of 86 first-degree relatives of I 5 families. Tests were performed with blood monocytes using (G-3H)-benzo[a]pyrene as a model pro-carcinogen. Variance analysis revealed significantly higher inter-familial than intra-
## Abstract In this study, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were used to determine the inhibition of arylamine __N__βacetyltransferase (NAT) activity and DNA adduct formation in human bladder tumour cell line Tβ24. The activity of NAT was measured by highβperformanc