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Formation of dna adducts and water-soluble metabolites of benzo[a]pyrene in human monocytes is genetically controlled

✍ Scribed by Dennis Nowak; Ute Schmidt-Preuss; Rudolf Jörres; Frank Liebke; Hugo W. Rüdiger

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
511 KB
Volume
41
Category
Article
ISSN
0020-7136

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✦ Synopsis

Formation of DNA adducts and of water-soluble metabolites was studied in monocytes of 86 first-degree relatives of I 5 families. Tests were performed with blood monocytes using (G-3H)-benzo[a]pyrene as a model pro-carcinogen. Variance analysis revealed significantly higher inter-familial than intra-familial variations. From these data we conclude that the formation of DNA adducts is genetically controlled. Therefore the enhanced formation of benzo[a]pyrene DNA adducts in lung cancer patients found in earlier studies may reflect a genetic predisposition for lung cancer in some patients.

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