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Genetic study of pancreatic proteinase in mice (Mus musculus): Genetic variants of trypsin and chymotrypsin

โœ Scribed by Tomomasa Watanabe; Nobuaki Ogasawara; Haruko Goto

Publisher
Springer
Year
1976
Tongue
English
Weight
518 KB
Volume
14
Category
Article
ISSN
0006-2928

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โœฆ Synopsis

Three to five isozymes of pancreatic proteinase exist in mice, and they have been designated as bands I, II, III, IV, and V. Identification experiments of these isozymes were carried out in this study; bands I, IV, and V are trypsin, and bands II and III are chymotrypsin. Therefore, it is concluded that Prt-1, controlling band V, is a locus for trypsin and Prt-2, controllong bands II and III, is a locus for chymotrypsin. In addition, a new locus, Prt-3, has been found. At this locus the two allelic genes, Prt-3a and Prt-3b, control the low and high tryptic activities of band IV, respectively. Prt-3 is present only in the strain Mol-A. Linkage experimentation has shown that Prt-1 is closely linked to Prt-3.

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Genetic study of pancreatic proteinase in mice (Mus musculus): Linkage of thePrt-2locus on chromosome 8
โœ Tomomasa Watanabe; Nobuaki Ogasawara; Haruko Goto ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 181 KB

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Various patterns of mouse pancreatic proteinase activity bands were observed on agarose gel electrophoresis. Prt-1a and Prt-1b genes control the positive (PRT-1A) and negative (PRT-1B) expression of tryptic band V, respectively; Prt-2a and Prt-2b correspond to chymotryptic bands II (PRT-2A) and III