Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylas
Genetic study of dopamine-related genes in unipolar affective disorder
β Scribed by G.N. Papadimitriou; D.G. Dikeos; G. Karadima; E.G. Daskalopoulou; D. Avramopoulos; C.N. Stefanis
- Book ID
- 118600585
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 169 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0924-977X
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The serotonin transporter is a compelling candidate gene to examine in bipolar and unipolar affective disorder, since drugs that specifically inhibit the serotonin transporter can successfully treat depression. Previous association studies of a VNTR polymorphism in intron 2 and a functional insertio
## Abstract Convincing evidence for a genetic component in the etiology of affective disorders (AD), including bipolar affective disorder (BPAD) and unipolar affective disorder (UPAD), is supported by traditional and molecular genetic studies. Most arguments lead to the complex inheritance hypothes