## Abstract There are increasing reports showing the clinical significance of the __p53__ polymorphism status in terms of the response to chemotherapy. We investigated whether __p53__ polymorphism and mutation were associated with __in vitro__ sensitivity to 5βfluorouracil (5βFU) in patients with c
Genetic status of p53 in stomach cancer: Somatic mutations and polymorphism of codon 72
β Scribed by V. A. Belyavskaya; V. K. Vardosanidze; O. Yu. Smirnova; E. I. Karakin; I. V. Savkin; P. A. Gervas; N. V. Cherdyntseva; M. I. Voevoda
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 287 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0007-4888
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Studies investigating the association between p53 codon 72 polymorphism and gastric cancer risk report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline and Embase d
## Abstract The p53 gene is involved in the control of cellβcycle arrest and apoptosis. The germline Arg72Pro polymorphism alters the protein's biochemical functions, and may confer individual susceptibility to skin cancer. We evaluated the association of the Arg72Pro polymorphism with skin cancer
## Abstract __In vitro__ studies suggest that __p__53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wildβtype p53 harboring a greater apoptosisβinducing potential than the 72 proline (P) variant. The aim of this study was to investigate whether the