## Abstract The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helixโdistorting DNA lesions. Several polymorphisms of __XPC__ gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of __XPC__ Lys939Gln (A/C), Ala499Val (C/T
Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population
โ Scribed by KUN CHEN; MINGJUAN JIN; YIMIN ZHU; QINTING JIANG; WEIPING YU; XINYUAN MA; KAIYAN YAO
- Book ID
- 108950477
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 80 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0815-9319
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## Abstract ## __Background.__ UGT1A7 is an enzyme involved in the metabolism of (pre)carcinogens present in tobacco smoke. We investigated whether genetic polymorphisms in __UGT1A7__, with predicted altered enzyme activity, may have a riskโmodifying effect on head and neck carcinogenesis. ## __M