The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population

✍ Scribed by Yinyin Wu; Mingjuan Jin; Bing Liu; Xia Liang; Yunxian Yu; Qilong Li; Xinyuan Ma; Kaiyan Yao; Kun Chen

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 105 KB
• Volume: 50
• Category: Article
• ISSN: 0899-1987
• DOI: 10.1002/mc.20704

✦ Synopsis

Abstract

The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helix‐distorting DNA lesions. Several polymorphisms of XPC gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of XPC Lys939Gln (A/C), Ala499Val (C/T), and PAT (−/+) polymorphisms with CRC risk in a population‐based case–control study which included 421 CRC patients and 845 controls. For Lys939Gln, the CC genotype was associated with a significantly increased risk of CRC (odds ratio (OR) = 1.5; 95% confidence interval (CI) = 1.0−2.2) compared with the AA genotype. The subjects with PAT +/+ genotype had a significantly increased risk of CRC (OR = 1.5; 95% CI = 1.0−2.3), compared with those with PAT−/− genotype. Though no significant association between Ala499Val and CRC risk was observed, we found that individuals carrying the CT + TT genotypes showed a significantly decreased risk of rectal cancer (OR = 0.7; 95% CI = 0.5−1.0). Additionally, the haplotype C + C was associated with a significantly increased CRC risk (OR = 1.3; 95% CI = 1.0−1.6), compared with the most common haplotype A‐T. Further, individuals with four or more risk alleles exhibited a significantly increased risk of CRC (OR = 1.4; 95% CI = 1.0−2.0), with a significant gene‐dosage effect (P for trend = 0.038). Besides, never tea drinking was associated with a significantly increased risk of CRC (OR = 2.3; 95% CI = 1.7−3.3). Our results suggest that the XPC polymorphisms may modulate CRC susceptibility independently or jointly, and tea drinking has a protective effect on CRC. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.