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Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: The Self Defense Forces Health Study

✍ Scribed by Naoyuki Ueda; Yoshihiko Maehara; Osamu Tajima; Shinji Tabata; Keiji Wakabayashi; Suminori Kono


Book ID
108584103
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
91 KB
Volume
99
Category
Article
ISSN
1347-9032

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## Abstract Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke. Two coding‐region __mEH__ variants (Tyr113His, His139Arg) and __CYP2C9__ variants (Arg144Cys, I