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Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma

✍ Scribed by Zhihong Gong; Roberd M. Bostick; Dawen Xie; Thomas G. Hurley; Zonglin Deng; Dan A. Dixon; Jinhui Zhang; James R. Hebert

Publisher
Springer
Year
2009
Tongue
English
Weight
155 KB
Volume
24
Category
Article
ISSN
0179-1958

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## Abstract ## BACKGROUND. Lipoxygenases (__LOX__) are major enzymes that metabolize arachidonic acid to hydroxyl‐eicosatetraenoic acids and leukotrienes, which have been implicated in inflammation and colorectal cancer risk. Polymorphisms in __LOX__ genes may influence their function and/or expre