Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer
β Scribed by Kenji Shibuta; Tsuyoshi Eto; Akemi Kataoka; Hiroshi Inoue; Hiroaki Ueo; Tomokazu Suzuki; Graham F Barnard; Masaki Mori
- Book ID
- 119391916
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 90 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0002-9270
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The acetylation polymorphism is a common inherited variation in human drug and carcinogen metabolism. Because Nacetyltransferase (NAT2) is important for the detoxification and/or bioactivation of drugs and carcinogens, polymorphisms of this gene have important implications in therapeutics of and sus
Although inconsistencies exist, some studies have shown that meat consumption is associated with breast cancer risk. Several heterocyclic amines (HAs), formed in the cooking of meats, are mammary carcinogens in laboratory models. HAs are activated by polymorphic N-acetyltransferase (NAT2) and rapid