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Genetic polymorphism of alpha-1-antitrypsin in macaque species

โœ Scribed by E. Samilchuk; S. Sarsaniya


Publisher
Springer Japan
Year
1994
Tongue
English
Weight
690 KB
Volume
35
Category
Article
ISSN
0032-8332

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Liver disease in alpha-1-antitrypsin (alpha1AT) deficiency is caused by a gain-of-toxic function mechanism engendered by the accumulation of a mutant glycoprotein in the endoplasmic reticulum (ER). The extraordinary degree of variation in phenotypical expression of this liver disease is believed to