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Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER (+) breast cancer

✍ Scribed by Napoli, Nicola; Rastelli, Antonella; Ma, Cynthia; Yarramaneni, Jayasree; Vattikutti, Swapna; Moskowitz, Gerard; Giri, Tusar; Mueller, Cheryl; Kulkarny, Vibhati; Qualls, Clifford; Ellis, Matthew; Armamento-Villareal, Reina


Book ID
121889973
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
274 KB
Volume
55
Category
Article
ISSN
8756-3282

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## Abstract ## BACKGROUND. Letrozole is safe and effective in postmenopausal women with estrogen receptor‐positive early breast cancer, but long‐term aromatase inhibitor use may cause bone loss and increase fracture risk. This study evaluated an immediate or delayed strategy of bone protection the