Genetic Polymorphism and Activities of Human Colon Alcohol and Aldehyde Dehydrogenases: No Gender and Age Differences
β Scribed by Shih-Jiun Yin; Chin-Shya Liao; Ye-Chan Lee; Chew-Wun Wu; Shu-Wen Jao
- Book ID
- 114749419
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 752 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0145-6008
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## Abstract Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are most abundant in the liver, are the main enzymes involved in ethanol metabolism in humans. Genderβrelated differences in total liver ADH and ALDH activity among different animal species have been observed in many s
Two types of factors can theoretically modulate alcohol metabolism toward increased acetaldehyde production. These factors are the following: (a) individual, genetically determined isoenzymes with distinct catalytic properties, and (b) modifications of enzyme activity induced by alcohol itself or li