## Abstract ## Objective To examine whether the affected firstβdegree relatives within multicase systemic sclerosis (SSc; scleroderma) families are concordant for autoantibody profile, disease type, and HLA class II haplotypes and whether clinical expression and serologic characteristics of famili
Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis
β Scribed by Melanie J. Percy; Elisa Rumi
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 240 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
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The clinical features of familial Parkinson's disease (PD) were investigated by examining the families of 20 British probands who were selected on the basis of having clinically typical PD and at least one affected relative. Forty-nine secondary cases were identified. These subjects were clinically
## Abstract ## Background Familial factors are clearly associated with an increased risk of developing late onset Alzheimer's disease (LOAD). However, there is emerging evidence to suggest that familial factors may also influence clinical phenotype. To date, most studies have focussed on familial