𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A clinical and genetic study of familial Parkinson's disease

✍ Scribed by Dr. D. M. Maraganore; A. E. Harding; C. D. Marsden

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
591 KB
Volume
6
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

The clinical features of familial Parkinson's disease (PD) were investigated by examining the families of 20 British probands who were selected on the basis of having clinically typical PD and at least one affected relative. Forty-nine secondary cases were identified. These subjects were clinically indistinguishable from sporadic cases of idiopathic PD. If it is assumed that familial PD has a genetic basis, pedigree and segregation analysis suggested autosomal dominant inheritance of a gene or genes with reduced penetrance as the most likely explanation. The data did not support the possibilities of either mitochondrial or polygenic inheritance, although the latter cannot be excluded. The role of genetic factors in sporadic cases of PD remains unclear.

πŸ“œ SIMILAR VOLUMES

Familial aggregation of Parkinson's dise
Familial aggregation of Parkinson's disease: The Mayo Clinic family study
✍ Walter A. Rocca; Shannon K. McDonnell; Kari J. Strain; James H. Bower; J. Eric A πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 229 KB πŸ‘ 2 views

## Abstract Data on the familial aggregation of Parkinson's disease (PD) remain conflicting. We conducted a historical cohort study of 1,001 first‐degree relatives of 162 probands with PD and of 851 relatives of 147 control probands representative of the population of Olmsted County, Minnesota (fro

Clinical correlates of depressive sympto
Clinical correlates of depressive symptoms in familial Parkinson's disease
✍ Nathan Pankratz; Karen S. Marder; Cheryl A. Halter; Alice Rudolph; Cliff W. Shul πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 108 KB πŸ‘ 1 views

## Abstract Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between de

Genetics of Parkinson's disease and park
Genetics of Parkinson's disease and parkinsonism
✍ John Hardy; Huaiban Cai; Mark R. Cookson; Katrina Gwinn-Hardy; Andrew Singleton πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 174 KB πŸ‘ 3 views
Dopaminergic function in familial Parkin
Dopaminergic function in familial Parkinson's disease: A clinical and 18F-dopa positron emission tomography study
✍ Dr P. Piccini; P. K. Morrish; N. Turjanski; G. V. Sawle; D. J. Burn; R. A. Weeks πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 790 KB

There is increasing evidence for familial aggregation in Parkinson's disease (PD). It is possible that some asymptomatic relatives of I'D patients have subclinical nigral Lewy body pathology and their identification could help determine the true prevalence of the disease. We used 18F-dopa positron e