Genetic mechanisms in von Hippel-Lindau disease
β Scribed by Filling-Katz, MicheleR; Choyke, PeterL; Maher, E.R; Langenbeck, Ulrich
- Book ID
- 122080983
- Publisher
- The Lancet
- Year
- 1991
- Tongue
- English
- Weight
- 794 KB
- Volume
- 337
- Category
- Article
- ISSN
- 0140-6736
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Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital polycythemia, and are found in many sporadic tumor types as well. Reports of VHL mutations are dispersed throughout original articles and databases that have not been recently updated. We compiled a comprehensi
## Abstract Von HippelβLindau (VHL) disease is an uncommon, autosomal dominant hereditary multitumor syndrome caused by germline alterations of the __VHL__ gene, which has been cloned recently and identified as a tumor suppressor gene. The major lesions in VHL disease include hemangioblastomas in t