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Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours

✍ Scribed by Paul A. Crossey; Keith Foster; Frances M. Richards; Maude E. Phipps; Farida Latif; Kalman Tory; Michael H. Jones; Elizabeth Bentley; Ram Kumar; Michael I. Lerman; Bert Zbar; Nabeel A. Affara; Malcolm A. Ferguson-Smith; Eamonn R. Maher

Publisher
Springer
Year
1994
Tongue
English
Weight
616 KB
Volume
93
Category
Article
ISSN
0340-6717

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Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1