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Genetic markers and graves' disease: study of the fourth component complement alleles (C4)

✍ Scribed by A.M. Leguerrier; H. Allannic; R. Fauchet; Y. Lorcy; M. Guequen; H. Pheng Savath; B. Genetet

Book ID: 116004951
Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 93 KB
Volume: 20
Category: Article
ISSN: 0022-4731
DOI: 10.1016/0022-4731(84)90974-9

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The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p less than 0.00001); C4BQ0 was more frequent in