Genetic Polymorphism of the Fourth Component of Human Complement
β Scribed by G. Mauff; K. Bender; Barbara Fischer
- Book ID
- 115107968
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 326 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0042-9007
No coin nor oath required. For personal study only.
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Proteins were separated by prolonged isoelectric focusing in polyacrylamide gels, whereupon C2 bands were detected by a specific hemolytic assay. This was performed by treating the gel with iodine to increase C2 activity, and then developing C2 bands with an agarose gel overlay containing sensitized
The complement proteins, Bf, C2, C4A and C4B, are closely linked to HLA. In 74 propositi and their families, and 97 controls genotyped for HLA-A, -B, -C, DR, -Bf, a high incidence of the C4BQ0 variant was detected in the patient group (33% versus 12%, p less than 0.00001); C4BQ0 was more frequent in
An assessment has been made of the polymorphism of human complement component C4 by comparing derived amino acid sequences of cDNA and genomic DNA with limited amino acid sequences. In all, one complete and six partial sequences have been obtained from material from three individuals and include two