Genetic mapping of the component chains of Ia antigens
✍ Scribed by Jack Silver; William A. Russell
- Publisher
- Springer-Verlag
- Year
- 1979
- Tongue
- English
- Weight
- 454 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0093-7711
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## Abstract Studies with two monoclonal antibodies (DA6.147 and DA6.231) which react, respectively, with isolated human Ia α and β chains are reported. Both antibodies detect epitopes expressed on all DR‐heterozygous and DR‐homozygous cell lines tested (n = 17) and bind to the Epstein‐Barr virus‐ne
The Ia.8 and 9 specificities detected either by conventional or monoclonal antisera (Ia.m3, 4) are present in strains bearing the b H-2 haplotype, but absent from those with the k haplotype. It would be expected that the (b x k)F1 hybrids would have approximately half the amount of these specificiti