Genetic Mapping and DNA Sequencing

✍ Scribed by Mary Sara McPeek (auth.), Terry Speed, Michael S. Waterman (eds.)

• Publisher: Springer-Verlag New York
• Year: 1996
• Tongue: English
• Leaves: 228
• Series: The IMA Volumes in Mathematics and its Applications 81
• Edition: 1
• Category: Library

✦ Synopsis

Genetics mapping, physical mapping and DNA sequencing are the three key components of the human and other genome projects. Statistics, mathematics and computing play important roles in all three, as well as in the uses to which the mapping and sequencing data are put. This volume edited by key researchers Mike Waterman and Terry Speed reviews recent progress in the area, with an emphasis on the theory and application of genetic mapping.

✦ Table of Contents

Front Matter....Pages i-xi
An Introduction to Recombination and Linkage Analysis....Pages 1-14
Monte Carlo Methods in Genetic Analysis....Pages 15-38
Interference, Heterogeneity and Disease Gene Mapping....Pages 39-48
Estimating Crossover Frequencies and Testing for Numerical Interference with Highly Polymorphic Markers....Pages 49-63
What is a genetic map function?....Pages 65-88
Haplotyping Algorithms....Pages 89-110
Statistical Aspect of Trait Mapping Using a Dense Set of Markers: A Partial Review....Pages 111-131
A Comparative Survey of Non-Adaptive Pooling Designs....Pages 133-154
Parsing of Genomic Graffiti....Pages 155-181
Improving DNA Sequencing Accuracy and Throughput....Pages 183-206
Assembly of Shotgun Sequencing Data....Pages 207-215
Back Matter....Pages 216-221

✦ Subjects

Probability Theory and Stochastic Processes