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Genetic linkage between the loci for myotonic dystrophy and peptidase D

✍ Scribed by T. O'BRIEN; S. BALL; M. SARFARAZI; P. S. HARPER; E. B. ROBSON


Book ID
115249074
Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
234 KB
Volume
47
Category
Article
ISSN
0003-4800

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A set of nine polymorphic loci defined by DNA probes was studied for linkage with the disease locus in ten families with a history of Duchenne muscular dystrophy (DMD), and three families with a history of Becker muscular dystrophy (BMD). The results confirm DMD and BMD linkage to all marker loci an

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We used the following polymorphic markers: APOC2 (BanI, BglI, TaqI), CKMM (NcoI, TaqI), and D19S63 (PstI) to haplotype 33 Spanish myotonic dystrophy (DM) families. We analysed the allele and haplotype frequencies of our sample, and the possible association of alleles or haplotypes with the disease.