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Genetic linkage study between the loci for Duchenne and Becker muscular dystrophy and nine X-chromosomal DNA markers

โœ Scribed by E. Wilichowski; M. Krawczak; E. Seemanova; F. Hanefeld; J. Schmidtke

Publisher
Springer
Year
1987
Tongue
English
Weight
650 KB
Volume
75
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

A set of nine polymorphic loci defined by DNA probes was studied for linkage with the disease locus in ten families with a history of Duchenne muscular dystrophy (DMD), and three families with a history of Becker muscular dystrophy (BMD). The results confirm DMD and BMD linkage to all marker loci and suggest closer linkage of several probes than hitherto detected. This will be of practical interest for risk calculations in affected families.

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Genetic linkage relationships between the Xg blood group system and two X chromosome DNA polymorphisms in families with Duchenne and Becker muscular dystrophy
โœ M. Sarfarazi; P. S. Harper; H. M. Kingston; J. M. Murray; T. O'Brien; K. E. Davi ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 247 KB

The existence of linkage has been investigated between the Xg blood group system, two DNA restriction fragment length polymorphisms (RFLPs) located on the short arm of the X chromosome, Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). No linkage was found between the Xg locus a