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Genetic evidence for a tumor suppressor role of HIF-2α

✍ Scribed by Till Acker; Antonio Diez-Juan; Julian Aragones; Marc Tjwa; Koen Brusselmans; Lieve Moons; Dai Fukumura; Maria Paz Moreno-Murciano; Jean-Marc Herbert; Angelika Burger; Johanna Riedel; Gerd Elvert; Ingo Flamme; Patrick H. Maxwell; Désiré Collen; Mieke Dewerchin; Rakesh K. Jain; Karl H. Plate; Peter Carmeliet

Book ID
113523592
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
878 KB
Volume
8
Category
Article
ISSN
1535-6108

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✍ Jianmin Huang; Yan-Ling Zhao; Yu Li; Jonathan A. Fletcher; Sheng Xiao 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 479 KB

## Abstract __ARID1A__ is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified __ARID1A__ as a presumptive tumor suppressor gene. The transforming __ARID1A__ sequence was an antisense cDNA, and was the pr