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Genomic and functional evidence for an ARID1A tumor suppressor role

✍ Scribed by Jianmin Huang; Yan-Ling Zhao; Yu Li; Jonathan A. Fletcher; Sheng Xiao

Book ID
102220891
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
479 KB
Volume
46
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

ARID1A is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified ARID1A as a presumptive tumor suppressor gene. The transforming ARID1A sequence was an antisense cDNA, and was the product of a genomic rearrangement, as corroborated in the primary breast carcinoma from which the cDNA had been obtained. In further screening, we identified a lung adenocarcinoma cell line with a highly localized homozygous genomic deletion involving the 5β€² end of ARID1A. These studies provide strong evidence that ARID1A is a tumor suppressor gene. Β© 2007 Wiley‐Liss, Inc.

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