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Genetic Dissection of the Control of Normal Differentiation in Myeloid Leukemic Cells

✍ Scribed by Joseph Lotem and Leo Sachs

Book ID
123654626
Publisher
National Academy of Sciences
Year
1977
Tongue
English
Weight
787 KB
Volume
74
Category
Article
ISSN
0027-8424

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πŸ“œ SIMILAR VOLUMES

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. XII. Isolation of normal myeloid colony-forming cells from bone marrow and the sequence of differentiation to mature granulocytes in normal and D+ myeloid leukemic cells
✍ Joseph Lotem; Leo Sachs πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 931 KB

## Abstract An enriched population of early myeloid cells has been obtained from normal mouse bone marrow by injection of mice with sodium caseinate and the removal of cells with C3 (EAC) rosettes by Ficoll‐Hypaque density centrifugation. This enriched population had no EAC or Fc (EA) rosettes and

Control of normal differentiation of mye
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✍ Makoto Hayashi; Eitan Fibach; Leo Sachs πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 French βš– 548 KB

## Abstract A line of mouse myeloid leukemic cells in culture contained two types of clones. One type can be induced by the differentiation‐inducing protein MGI to undergo normal differentiation to mature macrophages and granulocytes (D^+^ clones), whereas the other type could not be induced to dif

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. XI. Induction of a specific requirement for cell viability and growth during the differentiation of myeloid leukemic cells
✍ Eitan Fibach; Leo Sachs πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

## Abstract Normal hematopoietic cells require the presence of a protein (MGI) in the appropriate conditioned medium (CM) for cell viability and growth and for differentiation to mature macrophages and granulocytes. Clones of myeloid leukemic cells have been established in culture (D^+^ clones) whi

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. VIII. Induction of differentiation to mature granulocytes in mass culture
✍ Eitan Fibach; Leo Sachs πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 741 KB

## Abstract There are three types of myeloid leukemic cells, IR^+^D^+^, IR^+^D^βˆ’^ and IR^βˆ’^D^βˆ’^. IR^+^D^+^ cells were induced to differentiate to granulocytes in mass culture in liquid medium by conditioned medium (CM) from cultures of lungs from mice injected with endotoxin. About 90% of the leuke

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. IV. Induction of differentiation by serum from endotoxin treated mice
✍ Eitan Fibach; Leo Sachs πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 767 KB

## Abstract Sera from different strains of mice injected with endotoxin induced clones (D^+^) from a cultured line of myeloid leukemic cells to undergo normal differentiation to mature granulocytes and macrophages. Other clones (D^βˆ’^) derived from the same cell line were not inducible by these sera