Genetic Dissection of Complex Traits

✍ Scribed by D. C. Rao

• Publisher: Academic Press
• Year: 2001
• Tongue: English
• Leaves: 571
• Series: Advances in Genetics 42
• Edition: 1
• Category: Library

✦ Synopsis

Genetic Dissection of Complex Traits will present the full range of methodologies that are essential for understanding the basis of human genetic disorders, the origin of such diseases, and theories on how to determine one's genetic predisposition to certain genetic diseases.

✦ Table of Contents

Content:
Contributors
Pages xv-xvii

Preface
Pages xix-xx
D.C. Rao, M.A. Province

Acknowledgments
Page xxi

1 Newton Morton: The Wisconsin years Review Article
Pages 3-5
James F. Crow

Newton Morton's influence on genetics: The Morton number Review Article
Pages 7-10
Daniel E. Weeks

3 Genetic dissection of complex traits: An overview Review Article
Pages 13-34
D.C. Rao

4 Familial resemblance and heritability Review Article
Pages 35-44
Treva K. Rice, Ingrid B. Borecki

5 Linkage and association: Basic concepts Review Article
Pages 45-66
Ingrid B. Barecki, Brian K. Suarez

6 Definition of the phenotype Review Article
Pages 69-76
John P. Rice, Nancy L. Saccone, Erik Rasmussen

7 Genotyping for human whole-genome scans: Past, present, and future Review Article
Pages 77-96
James L. Weber, Karl W. Broman

8 The lod score method Review Article
Pages 99-113
John P. Rice, Nancy L. Saccone, Jonathan Corbett

9 Extension of the lod score: The mod score Review Article
Pages 115-124
Françoise Clerget-Darpoux

10 Major strengths and weaknesses of the lod score method Review Article
Pages 125-132
Jurg Ott

11 Overview of model-free methods for linkage analysis Review Article
Pages 135-150
Robert C. Elston, Heather J. Cordell

12 Variance component methods for detecting complex trait loci Review Article
Pages 151-181
John Blangero, Jeff T. Williams, Laura Almasy

13 Linkage and association with structural relationships Review Article
Pages 183-190
Michael A. Province

14 The future of genetic case-control studies Review Article
Pages 191-212
Nicholas J. Schork, Dani Fallin, Bonnie Thiel, Xiping Xu, Ulrich Broeckel, Howard J. Jacob, Daniel Cohen

15 Cost of linkage versus association methods Review Article
Pages 213-221
Christopher I. Amos, Grier Page

16 Genotype-environment interaction in transmission disequilibrium tests Review Article
Pages 223-240
Lindon J. Eaves, Patrick Sullivan

17 Major strengths and weaknesses of model-free methods Review Article
Pages 241-251
David E. Goldgar

18 Meta-analysis for model-free methods Review Article
Pages 255-272
Chi Gu, Michael A. Province, D.C. Rao

19 Classification methods for confronting heterogeneity Review Article
Pages 273-286
Michael A. Province, W.D. Shannon, D.C. Rao

20 Applications of neural networks for gene finding Review Article
Pages 287-297
Andrea Sherriff, Jurg Ott

21 Genome partitioning and whole-genome analysis Review Article
Pages 299-322
Nicholas J. Schorki

22 Deciphering the genetic architecture of a multivariate phenotype Review Article
Pages 323-347
Saurabh Ghosh, Partha P. Majumder

23 On the resolution and feasibility of genome scanning approaches Review Article
Pages 351-391
Joseph D. Terwilliger

24 The role of interacting determinants in the localization of genes Review Article
Pages 393-412
W.James Gauderman, Duncan C. Thomas

25 Linkage disequilibrium mapping: The role of population history, size, and structure Review Article
Pages 413-437
N.H. Chapman, E.A. Thompson

26 Optimum study designs Review Article
Pages 439-457
Chi Gu, D.C. Rao

27 One-stage versus two-stage strategies for genome scans Review Article
Pages 459-471
Xiuqing Guo, Robert C. Elston

28 Significance levels in genome scans Review Article
Pages 475-486
Glenys Thomson

29 False positives and false negatives in genome scans Original Research Article
Pages 487-498
D.C. Rao, Chi Gu

30 Sequential methods of analysis for genome scans Original Research Article
Pages 499-514
Michael A. Province

31 From genetics to mechanism of disease liability Review Article
Pages 517-533
Jean-Marc Lalouel

32 Complex inheritance: The 21st century Review Article
Pages 535-543
Newton E. Morton

Appendix
Pages 545-568

Subject index
Pages 569-583