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Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia

✍ Scribed by Sebastiani, Paola; Ramoni, Marco F; Nolan, Vikki; Baldwin, Clinton T; Steinberg, Martin H

Book ID
109919134
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
333 KB
Volume
37
Category
Article
ISSN
1061-4036

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## Abstract Chronic simple hypertransfusion (every 3 to 4 weeks) effectively prevents secondary stroke in children with sickle cell anemia but leads to iron overload despite chelation therapy. Conventional red blood cell exchange (C‐RBCx) has advantages over simple transfusion: no net iron gain and